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个人简介

吕强,男,19784月出生,特聘教授/博导,中国材料学会理事,首届江苏省杰出青年基金获得者。2002年获北京理工大学材料科学研究中心应用化学硕士,2007年获得清华大学材料系材料物理与化学博士。20078月至200910月在美国Tufts大学生物医学工程系David Kaplan教授课题组从事博士后工作;200911月加入苏州大学现代丝绸国家工程实验室。从2000年开始一直从事丝蛋白生物材料的研究工作,主要通过组装调控实现丝蛋白生物材料功能的主动设计,开发适用于不同领域的先进功能材料,迄今为止在Advanced Functional MaterialsBiomacromoleculesACS Applied Materials and Interfaces等国际权威期刊发表SCI论文70余篇,申请并获得国家发明专利20余项。主持完成国家自然科学基金等科研项目10余项,现主持国家重点研发计划战略性国际科技创新合作重点专项“生物医用材料制备技术和产品联合研发项目”,同国际上从事丝蛋白生物材料研究的顶尖团队建立了紧密合作。同国内医学、生物学等不同领域的顶尖团队合作,2015年获得国家科技进步一等奖,2016年获教育部科技进步二等奖、江苏省科技进步二等奖等奖励。

 

研究方向及主讲课程

主要研究方向:丝蛋白生物材料,丝蛋白功能材料。

主讲本科生课程:  

主讲研究生课程:

 

荣誉及主要获奖情况  

1. 组织工程皮肤构建在烧伤创面修复中的应用研究,中华医学科技奖二等奖2013年,排名2

2. 干细胞神经损伤修复,辽宁省科学技术二等奖,2015年,排名2

3. 中国人体表难愈合创面发生新特征与防治的创新理论与关键措施研究,国家科技进步一等奖,2015年,排名13

4. 基于纳米复合材料的干细胞神经损伤修复关键技术体系的创建和应用,教育部科学进步二等奖,2016年,排名2

5. 烧创伤创面修复相关材料的基础及应用研究,江苏省科技进步二等奖,2016年,排名2

 

近五年主持的科研项目

1. 国家重点研发计划战略国际合作项目,2016YFE0204400,丝蛋白生物材料的仿生功能设计及组织修复产品的开发,2017/09-2020/08,1080万,在研,主持

2. 国家重点基础研究发展计划, 2013CB934400,荧光硅纳米结构的设计、生物学效应及其用于生物荧光成像的基础研究,2013/01-2017/12, 500万,在研,参加

3. 江苏省杰出青年基金,BK2012009,丝蛋白纳米组装及其功能构建,2012/07-2016/06,100万,结题,主持

4. 国家重点基础研究发展计划,2012CB722302,干细胞与丝蛋白生物材料在仿生功能性皮肤构建及其运用中的作用和机制,2012/01-2014/12,200万,结题,子课题负责人

5. 国家自然科学基金面上项目,21174097,丝蛋白三维微纳结构的构建及其对细胞生长和分化的作用,2012/01-2015/12, 63万,结题,主持

 

近五年发表的代表性论文

1. Zhaozhao Ding, Hongyan Han, Zhihai Fan, Haijun Lu, Yonghuan Sang, Yuling Yao, Qingqing Cheng, Qiang Lu, David L Kaplan, Nanoscale silk-hydroxyapatite hydrogels for injectable bone biomaterials, ACS Applied Materials and Interfaces, 2017, 9, 16913-16921.

2. Liying Xiao, Shanshao Liu, Danyu Yao, Zhaozhao Ding, Zhihai Fan, Qiang Lu, David L Kaplan, Fabrication of silk scaffolds with nanomicroscaled structures and tunable stiffness, Biomacromolecules, 2017, 18, 2073-2079.

3. Zhaozhao Ding, Jie Ma, Wei He, Zili Ge, Qiang Lu, David L Kaplan, Simulation of ECM with silk and chitosan nanocomposite materials, Journal of Materials Chemistry B, 2017, 5, 4789-4796.

4. Liying Xiao, Guozhong Lu, Qiang Lu*, David Kaplan, Direct formation of silk nanoparticles for drug delivery, ACS Biomaterials Science and Engineering, 2016, 2: 2050-2057.

5. Zhaozhao Ding, Zhihai Fan, Xiaowei Huang, Qiang Lu*, Weian Xu, David Kaplan, Silk-hydroxyapatite nanoscale scaffolds with programmable growth factor delivery for bone repair, ACS Applied Materials and Interface, 2016, 8: 24463-24470.

6. Xiaodan Dong, Qun Zhao, Liying Xiao, Qiang Lu*, David Kaplan, Amorphous silk nanofiber solutions for fabricating silk-based functional materials, Biomacromolecules, 2016, 17: 3000-3006.

7. Hongchun Wu, Shanshan Liu, Liying Xiao, Xiaodan Dong, Qiang Lu*, David Kaplan, Injectable and pH-responsive silk nanofiber hydrogels for sustained anticancer drug delivery, ACS Applied Materials and Interface, 2016, 8: 17118-17126.

8. Weiqin Sheng, Guobin Zhu, Qiang Lu*, David Kaplan, Metal oxide nanomaterials with nitrogen-doped grapheme silk nanofiber complexes as templates, Particle and Particle Systems Characterization, 2016, 33: 286-292.

9. Zhaozhao Ding, Zhihai Fan, Xiaowei Huang, Shumeng Bai, Dawei Song, Qiang Lu*, David L Kaplan, Bioactive natural protein-hydroxyapatite nanocarriers for optimizing osteogenic differentiation of mesenchymal stem cells,  Journal of Materials Chemistry B2016, 4:3555-3561.

10. Qiang Lu*Shumeng BaiZhaozhao DingHui GuoZhengzhong ShaoHesun ZhuDavid L. KaplanHydrogel Assembly with Hierarchical Alignment by Balancing Electrostatic ForcesAdvanced Materials Interfaces20163: 1500687.

11. Hongyan HanHongyan NingShanshan LiuQiang Lu*Zhihai FanHaijun LuGuozhong LuDavid L. KaplanSilk Biomaterials with Vascularization CapacityAdvanced Functional Materials201626426-432

12. Shanshan LiuLijie LiuLiying XiaoQiang Lu*Hesun ZhuDavid L KaplanDesign of silk–vaterite microsphere systems as drug carriers with pH-responsive release behaviorJournal of Materials Chemistry B201538314-8320.

13. Shumeng BaiHongyan HanXiaowei HuangWeian XuDavid L. KaplanHesun ZhuQiang Lu*Silk scaffolds with tunable mechanical capability for cell differentiationActa Biomaterialia20152022-31.

14. Weiqin ShengGuobin ZhuDavid L KaplanChuanbao CaoHesun ZhuQiang Lu*Silk-regulated hierarchical hollow magnetite/carbon nanocomposite spheroids for lithium-ion battery anodesNanotechnology201526115603.

15. Yazhen PeiXi LiuShanshan Liu Qiang Lu*Jing LiuDavid KaplanHesun ZhuA mild process to design silk scaffolds with reduced beta-sheet structure and various topographies at nanometer scaleActa Biomaterialia201513168-176.

16. Lijie LiuXiuli ZhangXi LiuJing LiuGuozhong LuDavid L KaplanHesun ZhuQiang Lu*Biomineralization of stable and monodisperse vaterite microspheres using silk nanoparticlesACS Applied Materials & Interfaces201571735-1745.

17. Xiaowei HuangShumeng Bai Qiang Lu*Xi LiuShanshan LiuHesun ZhuOsteoinductive-nanoscaled silk/HA composite scaffolds for bone tissue engineering applicationJournal of Biomedical Materials Research Part B: Applied Biomaterials20151031402-1414.

18. Yi ZhangCencen ZhangLijie LiuDavid L. KaplanHesun ZhuQiang Lu*Hierarchical charge distribution controls self-assembly process of silk in vitroFrontiers of Materials Science20159382-391.

19. Fangfang HanShanshan LiuXi LiuYazhen PeiShumeng BaiHuijing ZhaoQiang Lu*Fengguo MaDavid L KaplanHusun ZhuWoven silk fabric-reinforced silk nanofibrous scaffolds for regenerating load-bearing soft tissuesActa Biomaterialia201410921-930.

20.  Shumeng BaiXiuli Zhang Qiang Lu*Weiqin ShengXi LiuBoju DongDavid KaplanHesun ZhuReversible hydrogel-solution system of silk with high beta-sheet contentBiomacromolecules2014153044-3051.

21. Shumeng BaiWweijing Zhang Qiang Lu*Quanhong MaDavid KaplanHesun ZhuSilk nanofiber hydrogels with tunable modulus to regulate nerve stem cell fateJournal of Materials Chemistry B201426590-6600.

22. Shasha LinGuozhong LuShanshan LiuShumeng Bai Qiang Lu*Xi LiuBaoqi ZuoDavid KaplanHesun ZhuNanoscale control of silks for nanofibrous scaffold formation with an improved porous structureJournal of Materials Chemistry B201422622-2633.

23. Xiaowei HuangXi LiuShanshan LiuAili Zhang Qiang Lu*David KaplanHesun ZhuBiomineralization regulation by nanosized features in silk fibroin proteins: Synthesis of water-dispersible nano-hydroxyapatiteJournal of Biomedical Materials Research Part B: Applied Biomaterials20141021720-1729.

24. Guozhong LuShanshan LiuShasha LinDavid KaplanQiang Lu*Silk porous scaffolds with nanofibrous microstructures and tunable propertiesColloids and Surfaces B: Biointerfaces201412028-37.

25.  Weiqin ShengJing LiuShanshan LiuQiang Lu*David L KaplanHesun ZhuOne-step synthesis of biiocompatible magnetite/silk fibroin core-shell nanoparticlesJournal of Materials Chemistry B201427394-7402.

26. Shanshan LiuChaofei DongGuozhong LuQiang Lu*Zhanxiong LiDavid L. KaplanHesun ZhuBilayered vascular grafts based on silk proteinsActa Biomaterialia201398991-9003.

27. Shumeng BaiShanshan LiuCencen ZhangWeian XuQiang Lu*Hongyan HanDavid L KaplanHesun ZhuControllable transition of silk fibroin nanostructures: An insight into in vitro silk self-assembly processActa Biomaterialia201397806-7813

28. Xiuli ZhangZhihai FanQiang Lu*Yongli HuangDavid L. KaplanHesun ZhuHierarchical biomineralization of calcium carbonate regulated by silk microspheresActa Biomaterialia201396947-6980.

29. Danyu YaoSen DongQiang Lu*Xiao HuDavid L. KaplanBingbo ZhangHesun ZhuSalt-leached silk scaffolds with tunable mechanical propertiesBiomacromolecules2012133723-3729.

30. Cencen ZhangDawei SongQiang Lu*Xiao HuDavid L. KaplanHesun ZhuFlexibility Regeneration of Silk Fibroin in VitroBiomacromolecules2012132148-2153.

31. Qiang Lu*Hesun ZhuCencen ZhangFeng ZhangBing ZhangDavid L KaplanSilk self-assembly mechanism and control-from thermodynamics to kineticsBiomacromolecules201213826-832.

32. Feng ZhangBaoqi ZuoZhihai FanZongguang XieQiang Lu*Xueguan g ZhangDavid L. Kaplan, Mechanisms and control of silk-based electrospinninBiomacromolecules201213798-804.

 

联系方式

办公电话:0512-67061649

电子邮箱: lvqiang78@suda.edu.cn